In New York City in 1900, Dr. John W. Thackery is named Chief of Medicine at the Knickerbocker hospital when his colleague, J.M. Christiansen, commits suicide after a fai ...

Already fuming over the hospital's faulty new electrical system, Thackery tasks Herman Barrow, The Knick's crooked superintendent, to deliver more cadavers so he and his ...

An old friend of Thackery's, Abbie Alford, arrives at the hospital seeking his help. She has lost most of her nose as the result of syphilis, which she acquired from her ...

Dr. Edwards is finally invited into the surgical theater but Thackery makes it clear that he's only there to guide Dr. Gallinger through the procedure. Herman Barrow is m ...

Gangster Bunky Collier shows up at the Knick after one of his pimps is shot in the leg. Thackery is called in to perform the surgery and is surprised to find Edwards ther ...

Having lost yet another patient while performing a Cesarean section, Thackery develops a completely new method to reduce the bleeding and invites Bertie Chickering to hel ...

Dr. Gallinger returns to the Knick to find his social order upended. Dr. Edwards is now a working member of the team with Thackery's full support. They are using his suct ...

Thackery's affair with Nurse Lucy Elkins continues. Bertie continues to pursue her. There is a shortage of cocaine due to the war in the Philippines and attacks on shippi ...

The Knick continues its slide into wrack and ruin, instigated by the recent riot and the cocaine shortage. Dr. Thackery is caught in a compromising position and Lucy in h ...

Thackery's drug habit is catching up with him. He is growing increasingly paranoid as he is unable to perform even when under the drug's influence. When he learns that Dr ...